After fertilization, mouse embryos go through preimplantation development to give rise to blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell lineage specification, are essential for the process. Recent advances in low-input epigenomics profiling techniques allow the analysis of these events at a molecular level, which revealed a critical role of epigenetic and chromatin reprogramming in ZGA and the first cell lineage specification. Additionally, the establishment of an in vitro embryonic stem cell (ESC) to two-cell embryo-like conversion system have also contributed to the molecular understanding of preimplantation development. In this review, we summarize recent advances in epigenetic regulation of mouse preimplantation development, point out the remaining questions, and propose strategies to tackle these questions.

中文翻译：

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小鼠植入前胚胎发育的表观遗传调控。

受精后，小鼠胚胎经过植入前发育以产生囊胚。两个关键分子事件，合子基因组激活 (ZGA) 和第一个细胞谱系规范，对于该过程至关重要。低输入表观基因组学分析技术的最新进展允许在分子水平上分析这些事件，这揭示了表观遗传和染色质重编程在 ZGA 和第一个细胞谱系规范中的关键作用。此外，体外胚胎干细胞（ESC）到双细胞胚胎样转化系统的建立也有助于对植入前发育的分子理解。在这篇综述中，我们总结了小鼠胚胎植入前发育表观遗传调控的最新进展，指出了剩余的问题，