Background:Parkinson’s disease with mild cognitive impairment (PD-MCI) or dementia (PDD) has been shown to be correlated with poor quality of life (QoL). The association between specific cognitive domains and QoL is less clear. Objective:To determine how the cognitive domains affect QoL in different cognitive states in PD. Methods:We recruited 600 PD patients, including 185 PD patients with normal cognition (PD-NC), 336 PD-MCI patients, and 79 PDD patients. All patients underwent a scale-based assessment (PDQ-39) for QoL, as well as clinical evaluations and neuropsychological tests. Results:Compared to PD-NC group, QoL became more impaired in the PD-MCI and PDD groups. Generalized linear model revealed that no neuropsychological test was significantly associated with QoL in PD-NC group; neuropsychological tests in attention and language domains were significantly associated with QoL in PD-MCI patients; neuropsychological tests in memory and language domains were significantly associated with QoL in PDD patients. Conclusions:Cognitive domains contribute differently to QoL in PD. These findings may prompt clinicians to target specific cognitive domains for improving QoL in the PD patients.

中文翻译：

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帕金森病的认知功能和生活质量：一项横断面研究。

背景：帕金森病伴轻度认知障碍 (PD-MCI) 或痴呆 (PDD) 已被证明与生活质量 (QoL) 差有关。特定认知领域与 QoL 之间的关联不太清楚。目的：确定认知域如何影响PD不同认知状态下的QoL。方法：我们招募了600名PD患者，其中185名认知正常（PD-NC）的PD患者，336名PD-MCI患者，79名PDD患者。所有患者都接受了基于量表的 QoL 评估 (PDQ-39)，以及临床评估和神经心理学测试。结果：与 PD-NC 组相比，PD-MCI 和 PDD 组的 QoL 受损程度更大。广义线性模型显示PD-NC组无神经心理测试与QoL显着相关；注意力和语言领域的神经心理学测试与 PD-MCI 患者的 QoL 显着相关；记忆和语言领域的神经心理学测试与 PDD 患者的 QoL 显着相关。结论：认知领域对 PD 中的 QoL 的贡献不同。这些发现可能会促使临床医生针对特定的认知领域来改善 PD 患者的 QoL。