Minimally invasive implantation of porous implants with large volume for in vivo filling proposes high requirements for material preparation. Porous scaffolds based on shape memory polymer (SMP) possess great potential for being delivered as the compact form via minimally invasive surgery. Here, poly (ε-caprolactone)-dienes (PCL-dienes) and crylic acid (AA) were polymerized and cross-linked to fabricate SMP scaffolds, the porous structure of which was created through particle leaching method. Three scaffolds, PAA-PCL20, PAA-PCL50 and PAA-PCL80 were fabricated with different content of PCL-dienes, possessing similar pore size (350 μm) and porosity (85%). PAA-PCL50 scaffold had a T_m of 38 °C, exhibiting shape fixing ability at room temperature and shape recovery ability at body temperature. All scaffolds showed limited interaction with cells. The cell adhesion rate of PAA-PCL50 scaffold was 55%, the highest among the three scaffolds. To promote cellular adhesion, PAA-PCL50 scaffold was mineralized via in situ precipitation, exhibiting CaP particles on the inner surfaces. The mineralized scaffold still exhibited well-performed deformation and shape memory ability, with higher cell adhesion rate (86%) and proliferation rate. In vivo implantation result indicated that the mineralized PAA-PCL50 scaffold better supported tissue invasion, holding a great promise to improve neo-tissue formation.

微创植入大体积多孔植入物用于体内填充对材料制备提出了很高的要求。基于形状记忆聚合物 (SMP) 的多孔支架具有通过微创手术以紧凑形式提供的巨大潜力。在这里，聚（ε-己内酯）-二烯（PCL-二烯）和丙烯酸（AA）聚合并交联以制造 SMP 支架，其多孔结构是通过颗粒浸出法产生的。三种支架，PAA-PCL20、PAA-PCL50 和 PAA-PCL80 用不同含量的 PCL-二烯制造，具有相似的孔径（350 μm）和孔隙率（85%）。PAA-PCL50 支架有一个 T _m38°C，在室温下表现出形状固定能力和在体温下形状恢复能力。所有支架都显示出与细胞的有限相互作用。PAA-PCL50支架的细胞粘附率为55%，是三种支架中最高的。为了促进细胞粘附，PAA-PCL50 支架通过原位沉淀矿化，在内表面显示出 CaP 颗粒。矿化支架仍然表现出良好的变形和形状记忆能力，具有更高的细胞粘附率（86%）和增殖率。体内植入结果表明，矿化的 PAA-PCL50 支架更好地支持组织侵袭，有望改善新组织的形成。