This paper describes a novel method for fabricating paper-based microfluidic devices using a laser beam scanning technique. Cellulose chromatography papers were treated with octadecyltrichlorosilane (OTS) to make them entirely hydrophobic. A photoacid generator (CPI-410S) was soaked into the paper, and irradiated with a 405-nm laser beam to induce acid generating reactions. Since the silyl ether bond between cellulose and OTS was cleaved by the hydrolysis reaction, the photo-irradiated area changed to hydrophilic. By scanning the laser beam using a Galvo mirror system, arbitrary shaped hydrophilic patterns were successfully created on the paper in 50 μm resolution. To the best of our knowledge, this is the first report on the fabrication of hydrophilic channels on the OTS-treated paper using photo-induced acid generation processes coupled with the laser beam scanning technique. Quantification of nitrite was demonstrated with the paper device made by this method.

本文描述了一种使用激光束扫描技术制造纸基微流体装置的新方法。纤维素层析纸经过十八烷基三氯硅烷 (OTS) 处理，使其完全疏水。将光致产酸剂（CPI-410S）浸入纸中，并用405 nm激光束照射以引发产酸反应。由于纤维素和OTS之间的甲硅烷基醚键因水解反应而断裂，因此光照射区域变为亲水性。通过使用振镜系统扫描激光束，成功在纸张上以 50 μm 分辨率创建任意形状的亲水图案。据我们所知，这是第一份关于使用光致酸生成过程结合激光束扫描技术在 OTS 处理的纸张上制造亲水通道的报告。用该方法制作的纸装置演示了亚硝酸盐的定量。