Ileal pouch-anal anastomosis (IPAA) is the surgical treatment of choice for medically refractory ulcerative colitis. Pouch-related complications, such as pouchitis, cuffitis, or fistulae, occur in up to 50% of patients. Nearly 1 in 5 patients develop pouch-related complications refractory to medical therapy, including biologics. Hypoxia has been suggested as a trigger for these chronic refractory complications, and treating hypoxia may be of therapeutic benefit in this patient population. We investigated the effectiveness of hyperbaric oxygen therapy (HBOT) for patients with medically refractory pouch-related complications.

中文翻译：

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高压氧疗法可有效治疗炎症和瘘管并发症。

回肠储袋肛门吻合术 (IPAA) 是治疗难治性溃疡性结肠炎的首选手术治疗方法。多达 50% 的患者会发生与储袋相关的并发症，例如储袋炎、袖带炎或瘘管。近五分之一的患者会出现药物治疗（包括生物制剂）难以治愈的储袋相关并发症。低氧被认为是这些慢性难治性并发症的触发因素，治疗低氧可能对这一患者群体具有治疗益处。我们调查了高压氧治疗 (HBOT) 对治疗难治性储袋相关并发症患者的有效性。