Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene.

牙龈卟啉单胞菌（Porphyromonas gingivalis）是牙周炎中的一种主要的龈下菌斑细菌，作为阿尔茨海默氏病的一种可能的微生物驱动因子，最近引起了人们的广泛关注。在本文中，讨论了另一种常见的神经炎性疾病，帕金森氏病（PD）。一项最新研究发现，PD人群血液循环中牙龈卟啉单胞菌的主要毒力因子，例如姜脂素R1（RgpA）和脂多糖。本篇综述揭示了可能由牙龈卟啉单胞菌引起的诸如全身性炎症，高凝，血浆淀粉样蛋白纤维蛋白（原）的存在以及血小板中明显的超微结构改变等特征，可能会影响PD的发展。其他几项临床研究也证明了牙周炎和PD之间的关联。即使需要更好地证实导致牙周疾病的神经系统疾病的风险，也不应阻止我们通过每天进行仔细的牙齿卫生来预防它们。