High amounts of aluminum (Al) are found in soil and water. It is highly bioavailable, which makes it an important agent of environmental imbalance. Moreover, Al is considered a neurotoxic agent that is associated with several neurodegenerative diseases. Thus, this study investigated the effects of long-term Al chloride (AlCl₃) exposure on motor behavior, oxidative biochemistry, and cerebellar tissue parameters. For this, adult Wistar rats were divided into three groups: Al-D1 (8.3 mg kg⁻¹ day⁻¹), Al-D2 (5.2 mg kg⁻¹ day⁻¹), and control (distilled water); all groups were orally exposed for 60 days by intragastric gavage. After the exposure period, animals performed the open field, elevated plus maze, rotarod, and beam walking tests. Then, the blood and cerebellum were collected to evaluate Al levels and biochemical and morphological analyses, respectively. Our results demonstrate that animals exposed to Al doses presented a higher Al level in the blood. In the spontaneous locomotor activity, Al exposure groups had traveled a lower total distance when compared with the control group. There was no statistically significant difference (p > 0.05) between exposed and control groups when anxiogenic profile, forced locomotion, fine motor coordination/balance, pro-oxidative parameter, and density Purkinje cells were compared. Thus, aluminum exposure in equivalent doses to human consumption in urban regions did not promote significant changes in the cerebellum or motor parameters.

在土壤和水中发现大量的铝（Al）。它具有很高的生物利用度，使其成为环境不平衡的重要因素。此外，Al被认为是与几种神经退行性疾病有关的神经毒性剂。因此，本研究调查了长期暴露于氯化铝（AlCl ₃）对运动行为，氧化生物化学和小脑组织参数的影响。为此，将成年Wistar大鼠分成三组：Al-D1（8.3 mg kg ^-1 天^-1），Al-D2（5.2 mg kg ^-1 天^-1））和控制（蒸馏水）；所有组均通过灌胃法经口暴露60天。暴露期过后，动物进行了野外，高架迷宫，旋转脚架和步道行走测试。然后，收集血液和小脑以评估Al水平以及分别进行生化和形态分析。我们的结果表明，暴露于铝剂量的动物血液中的铝含量较高。在自发运动活动中，与对照组相比，铝暴露组的总距离短。差异无统计学意义（p > 0.05）在暴露组和对照组之间比较焦虑发生情况，强迫运动，精细运动协调/平衡，促氧化参数和密度浦肯野细胞。因此，在城市地区以与人类食用同等剂量的铝暴露不会促进小脑或运动参数的显着变化。