It remains obscure whether circulating aortic zinc (Zn) and copper (Cu) levels are associated with the progress of human abdominal aortic aneurysms (AAA). Therefore, we conducted a meta-analysis to explore this relationship. A literature search on circulating and aortic zinc and copper levels and AAA patients was conducted using online databases including PubMed, Embase, and Cochrane up to March 20, 2019. To compare Zn and Cu concentrations in AAA patients with those in aortic occlusive disease (AOD) patients or healthy aorta donors or healthy blood donors, pooled weighted mean difference (WMD) and its 95% confidence interval (CI) were calculated. Subgroup analysis, sensitivity analysis, and meta-regression analysis were applied to explain the heterogeneity and evaluate the robustness of combined results. A total of 10 cross-sectional studies, including 252 cases and 304 controls, were used for meta-analysis. We found that circulating zinc and Zn/Cu ratio in AAA patients were significantly lower [WMD (95%CI): − 2.23 (− 4.10, − 0.36); − 0.18 (− 0.31, − 0.05), respectively] than those in non-AAA patients. Similarly, aneurysmal aorta had significantly lower zinc levels and Zn/Cu ratio [WMD (95%CI): − 9.22 (− 15.37, − 3.07); − 6.46 (− 10.14, − 2.77), respectively] than those in control group. No difference in circulating or aortic copper levels was noted between AAA patients and control group [WMD (95%CI): - 0.24 (- 2.09, 1.61); 0.30 (- 0.01, 0.61) , respectively]. Our meta-analysis suggests that zinc levels and Zn-Cu ratio, but not copper levels, may influence aneurysmal progress of AAA.

循环的主动脉锌（Zn）和铜（Cu）水平是否与人类腹主动脉瘤（AAA）的进展有关尚不清楚。因此，我们进行了荟萃分析以探讨这种关系。截至2019年3月20日，使用PubMed，Embase和Cochrane等在线数据库对循环和主动脉锌和铜水平以及AAA患者进行了文献检索。以比较AAA患者与主动脉闭塞性疾病（AOD）中的Zn和Cu浓度）患者或健康的主动脉供体或健康的血液供体，计算加权平均均值（WMD）及其95％置信区间（CI）。应用亚组分析，敏感性分析和元回归分析来解释异质性并评估合并结果的稳健性。共有10项横断面研究，包括252例病例和304例对照者，进行荟萃分析。我们发现AAA患者的循环锌和Zn / Cu比率显着降低[WMD（95％CI）：− 2.23（− 4.10，− 0.36）；分别为-0.18（-0.31，-0.05）]。同样，动脉瘤主动脉的锌水平和锌/铜比也显着降低[WMD（95％CI）：− 9.22（− 15.37，− 3.07）；-6.46（-10.14，-2.77）]。AAA患者与对照组之间的循环或主动脉铜水平无差异[WMD（95％CI）：-0.24（-2.09，1.61）；0.30（-0.01，0.61）分别]。我们的荟萃分析表明锌水平和Zn-Cu比而不是铜水平可能会影响AAA的动脉瘤进展。我们发现AAA患者的循环锌和Zn / Cu比率显着降低[WMD（95％CI）：− 2.23（− 4.10，− 0.36）；分别为-0.18（-0.31，-0.05）]。同样，动脉瘤主动脉的锌水平和锌/铜比也显着降低[WMD（95％CI）：− 9.22（− 15.37，− 3.07）；-6.46（-10.14，-2.77）]。AAA患者与对照组之间的循环或主动脉铜水平无差异[WMD（95％CI）：-0.24（-2.09，1.61）；0.30（-0.01，0.61）分别]。我们的荟萃分析表明，锌水平和Zn-Cu比而不是铜水平可能会影响AAA的动脉瘤进展。我们发现AAA患者的循环锌和Zn / Cu比率显着降低[WMD（95％CI）：− 2.23（− 4.10，− 0.36）；分别为-0.18（-0.31，-0.05）]。同样，动脉瘤主动脉的锌水平和锌/铜比也显着降低[WMD（95％CI）：− 9.22（− 15.37，− 3.07）；-6.46（-10.14，-2.77）]。AAA患者与对照组之间的循环或主动脉铜水平无差异[WMD（95％CI）：-0.24（-2.09，1.61）；0.30（-0.01，0.61）分别]。我们的荟萃分析表明锌水平和Zn-Cu比而不是铜水平可能会影响AAA的动脉瘤进展。动脉瘤性主动脉的锌水平和锌/铜比[WMD（95％CI）：− 9.22（− 15.37，− 3.07）；-6.46（-10.14，-2.77）]。AAA患者与对照组之间的循环或主动脉铜水平无差异[WMD（95％CI）：-0.24（-2.09，1.61）；0.30（-0.01，0.61）分别]。我们的荟萃分析表明锌水平和Zn-Cu比而不是铜水平可能会影响AAA的动脉瘤进展。动脉瘤性主动脉的锌水平和锌/铜比[WMD（95％CI）：− 9.22（− 15.37，− 3.07）；-6.46（-10.14，-2.77）]。AAA患者与对照组之间的循环或主动脉铜水平无差异[WMD（95％CI）：-0.24（-2.09，1.61）；0.30（-0.01，0.61）分别]。我们的荟萃分析表明锌水平和Zn-Cu比而不是铜水平可能会影响AAA的动脉瘤进展。