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Antioxidant Potential of Ulexite in Zebrafish Brain: Assessment of Oxidative DNA Damage, Apoptosis, and Response of Antioxidant Defense System.
Biological Trace Element Research ( IF 3.9 ) Pub Date : 2020-06-15 , DOI: 10.1007/s12011-020-02231-7 Gonca Alak 1 , Arzu Ucar 1 , Veysel Parlak 1 , Aslı Çilingir Yeltekin 2 , Fatma Betül Özgeriş 3 , Muhammed Atamanalp 1 , Hasan Türkez 4
Biological Trace Element Research ( IF 3.9 ) Pub Date : 2020-06-15 , DOI: 10.1007/s12011-020-02231-7 Gonca Alak 1 , Arzu Ucar 1 , Veysel Parlak 1 , Aslı Çilingir Yeltekin 2 , Fatma Betül Özgeriş 3 , Muhammed Atamanalp 1 , Hasan Türkez 4
Affiliation
In recent years, because of its significant biological roles, the usage of boron has been started in animal feeding. In this research, it was aimed to investigate the ulexite's action mechanism on the zebrafish brain with an evaluation of the oxidative parameters. The adult zebrafish were exposed to four ulexite doses (5, 10, 20, and 40 mg/l) in a static test apparatus for 96 h. For assessing the oxidative responses, multiple biochemical analyses were performed in brain tissues. The results indicated the supporting potential of low ulexite doses on the antioxidant system (< 40 mg/l) and that low-dose ulexite does not lead to oxidative stress in the zebrafish brain. Again, our results showed that low ulexite concentrations did not cause DNA damage or apoptosis. As a final result, in aquatic environments, ulexite (a boron compound) can be used in a safe manner, but it would be useful at higher concentrations to consider the damages of the cells that are probable to develop because of the oxidative stress.
中文翻译:
Ulexite 在斑马鱼脑中的抗氧化潜力:氧化 DNA 损伤、细胞凋亡和抗氧化防御系统反应的评估。
近年来,由于其重要的生物学作用,硼已开始用于动物饲养。在这项研究中,旨在通过评估氧化参数来研究 ulexite 对斑马鱼大脑的作用机制。成年斑马鱼在静态测试装置中暴露于四种 ulexite 剂量(5、10、20 和 40 毫克/升)96 小时。为了评估氧化反应,在脑组织中进行了多项生化分析。结果表明低剂量 ulexite 对抗氧化系统的支持潜力 (< 40 mg/l),并且低剂量 ulexite 不会导致斑马鱼大脑中的氧化应激。同样,我们的结果表明低 ulexite 浓度不会导致 DNA 损伤或细胞凋亡。结果,在水生环境中,
更新日期:2020-06-15
中文翻译:
Ulexite 在斑马鱼脑中的抗氧化潜力:氧化 DNA 损伤、细胞凋亡和抗氧化防御系统反应的评估。
近年来,由于其重要的生物学作用,硼已开始用于动物饲养。在这项研究中,旨在通过评估氧化参数来研究 ulexite 对斑马鱼大脑的作用机制。成年斑马鱼在静态测试装置中暴露于四种 ulexite 剂量(5、10、20 和 40 毫克/升)96 小时。为了评估氧化反应,在脑组织中进行了多项生化分析。结果表明低剂量 ulexite 对抗氧化系统的支持潜力 (< 40 mg/l),并且低剂量 ulexite 不会导致斑马鱼大脑中的氧化应激。同样,我们的结果表明低 ulexite 浓度不会导致 DNA 损伤或细胞凋亡。结果,在水生环境中,