ADA16 peptide hydrogels have been broadly used in tissue engineering due to their good biocompatibility and nanofibrous structure mimicking the native extracellular matrix (ECM). However, the low mechanical strength often fails them as implantable scaffolds. To improve the mechanical stability of the RADA16 peptide hydrogel, a photocrosslinkable diacrylated poly(ϵ-caprolactone)- b -poly(ethylene glycol)- b -poly(ϵ-caprolactone) triblock copolymer (PCECDA) was physically combined with RADA16 peptide pre-modified with cell adhesive Arg-Gly-Asp sequence (RADA16-RGD). Consequently, an interpenetrating network, RADA16-RGD/PCECDA, was formed with highly enhanced mechanical property. The storage modulus (G′) of RADA16-RGD/PCECDA (6% w/v, mass ratio m RADA16-RGD /m PCECDA = 1:5) hybrid hydrogel was elevated to ∼2000 Pa, compared to the RADA16-RGD (1% w/v) hydrogel alone (∼700 Pa). Furthermore, this hybrid hydrogel retained the nanofibrous structure from RADA...

中文翻译：

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机械强化混合肽-聚酯水凝胶及其在脊髓损伤修复中的潜在应用。

ADA16 肽水凝胶由于其良好的生物相容性和模拟天然细胞外基质 (ECM) 的纳米纤维结构而被广泛应用于组织工程。然而，低机械强度往往使它们无法作为可植入支架。为了提高 RADA16 肽水凝胶的机械稳定性，将可光交联的二丙烯酸酯化聚（ε-己内酯）-b-聚（乙二醇）-b-聚（ε-己内酯）三嵌段共聚物（PCECDA）与 RADA16 肽预物理结合。用细胞粘附 Arg-Gly-Asp 序列 (RADA16-RGD) 修饰。因此，形成了具有高度增强的机械性能的互穿网络 RADA16-RGD/PCECDA。RADA16-RGD/PCECDA（6% w/v，质量比 m RADA16-RGD /m PCECDA = 1:5）混合水凝胶的储能模量（G'）提高到~2000 Pa，与单独的 RADA16-RGD（1% w/v）水凝胶（~700 Pa）相比。此外，这种混合水凝胶保留了 RADA 的纳米纤维结构......