Objective. Cortical vision prostheses aim to restore visual percepts to those who have lost sight by delivering electrical stimulation to the visual cortex. These devices need to be implanted intracranially using subdural or intracortical microelectrodes, and should preferably dispense with the need of transcranial wiring. The risks of cortical tissue injury from mechanical trauma, material biocompatibility, heat generation, electrical stimulation and long-term immune responses need to be evaluated. In this paper, we investigate the biological response to a wireless cortical vision prosthesis (Gennaris array), by characterizing the histological changes that occur following chronic electrical stimulation. Approach. Ten arrays (7 active, 3 passive) were implanted in three sheep using a pneumatic insertor. Each device consisted of a wireless receiver and Application Specific Integrated Circuit encased in a ceramic box, and could deliver electrical stimulation through...

中文翻译：

---

组织对长期植入的无线皮质内视觉假体（Gennaris阵列）的反应。

目的。皮层视觉假体旨在通过向皮层传递电刺激，为失去视力的人恢复视觉知觉。这些装置需要使用硬膜下或皮层内微电极在颅内植入，并且最好应免除经颅布线的需要。机械损伤，材料生物相容性，生热，电刺激和长期免疫反应引起的皮质组织损伤的风险需要评估。在本文中，我们通过表征慢性电刺激后发生的组织学变化，研究了对无线皮质视觉假体（Gennaris阵列）的生物学反应。方法。使用气动插入器将十个阵列（7个主动，3个被动）植入三只绵羊。