Significant enhancement of the glycolysis pathway is a major feature of tumor cells, even in the presence of abundant oxygen; this enhancement is known as the Warburg effect, and also called aerobic glycolysis. The Warburg effect was discovered nearly a hundred years ago, but its specific mechanism remains difficult to explain. DNA methylation is considered to be a potential trigger for the Warburg effect, as the two processes have many overlapping links during tumorigenesis. Based on a widely recognized potential mechanism of the Warburg effect, we here summarized the relationship between DNA methylation and the Warburg effect with regard to cellular energy metabolism factors, such as glycolysis related enzymes, mitochondrial function, glycolysis bypass pathways, the tumor oxygen sensing pathway and abnormal methylation conditions. We believe that clarifying the relationship between these different mechanisms may further help us understand how DNA methylation works on tumorigenesis and provide new opportunities for cancer therapy.

中文翻译：

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DNA 甲基化如何影响 Warburg 效应。

糖酵解途径的显着增强是肿瘤细胞的一个主要特征，即使存在充足的氧气；这种增强被称为 Warburg 效应，也称为有氧糖酵解。瓦尔堡效应在近一百年前被发现，但其具体机​​制仍难以解释。DNA 甲基化被认为是 Warburg 效应的潜在触发因素，因为这两个过程在肿瘤发生过程中有许多重叠的联系。基于广泛认可的Warburg效应的潜在机制，我们在此总结了DNA甲基化与Warburg效应之间的关系，涉及细胞能量代谢因素，如糖酵解相关酶、线粒体功能、糖酵解旁路途径、肿瘤氧传感途径和异常甲基化条件。