In schizophrenia and related disorders, a deeper mechanistic understanding of neocortical dysfunction will be essential to developing new diagnostic and therapeutic techniques. To this end, combined transcranial magnetic stimulation and electroencephalography (TMS/EEG) provides a non-invasive tool to simultaneously perturb and measure neurophysiological correlates of cortical function, including oscillatory activity, cortical inhibition, connectivity, and synchronization. In this review, we summarize the findings from a variety of studies that apply TMS/EEG to understand the fundamental features of cortical dysfunction in schizophrenia. These results lend to future applications of TMS/EEG in understanding the pathophysiological mechanisms underlying cognitive deficits in schizophrenia.

中文翻译：

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通过 TMS/EEG 了解精神分裂症的皮质功能障碍

在精神分裂症和相关疾病中，对新皮质功能障碍的更深入机制理解对于开发新的诊断和治疗技术至关重要。为此，结合经颅磁刺激和脑电图 (TMS/EEG) 提供了一种非侵入性工具，可以同时扰乱和测量皮质功能的神经生理学相关性，包括振荡活动、皮质抑制、连接性和同步性。在这篇综述中，我们总结了各种研究的结果，这些研究应用 TMS/EEG 来了解精神分裂症皮质功能障碍的基本特征。这些结果有助于未来 TMS/EEG 在理解精神分裂症认知缺陷的病理生理机制方面的应用。