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The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer.
Archives of Medical Science ( IF 3.8 ) Pub Date : 2020-03-09 , DOI: 10.5114/aoms.2020.93535
Hai-Tao Huang 1 , Yi-Ming Xu 1 , Sheng-Guang Ding 1 , Xiao-Qiang Yu 1 , Fei Wang 1 , Hai-Feng Wang 2 , Xue Tian 3 , Chong-Jun Zhong 1
Affiliation  

INTRODUCTION Lung cancer is the leading cause of cancer-associated mortality worldwide. Recently, long non-coding RNAs (lncRNAs) have been studied as key regulators in some biological processes. Of note, the molecular mechanism and prognostic value of lncRNAs in non-small cell lung cancer (NSCLC) have largely remained unclear. MATERIAL AND METHODS In this study, we compared the PTTG3P expression levels between lung cancer and normal lung samples by analyzing 5 public datasets (GSE18842, GSE19804, GSE27262, GSE30219, and GSE19188). Next, pentose phosphate pathway and co-expression networks were constructed to identify key targets of lncRNA PTTG3P. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore the potential roles of lncRNA PTTG3P. Moreover, we constructed PTTG3P-mediated ceRNA networks in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). RESULTS In the present study, our analysis showed that PTTG3P expression was higher in high T stage LUAD and LUSC samples, as well as high N stage NSCLC tissues. Of note, we found that higher PTTG3P expression is correlated with shorter survival time in NSCLC patients by analyzing Kaplan-Meier plotter datasets. We found that PTTG3P was significantly associated with NSCLC cell proliferation regulation by affecting a series of cell cycle related biological processes. CONCLUSIONS Bioinformatics analysis showed that PTTG3P was associated with NSCLC cell proliferation. These results suggested that PTTG3P could serve as a new therapeutic and prognostic target for NSCLC.

中文翻译:

新型 lncRNA PTTG3P 被下调并预测非小细胞肺癌的不良预后。

引言 肺癌是全球癌症相关死亡的主要原因。最近,长链非编码 RNA (lncRNA) 已被研究为一些生物过程中的关键调节因子。值得注意的是,lncRNA 在非小细胞肺癌 (NSCLC) 中的分子机制和预后价值在很大程度上仍不清楚。材料与方法 在本研究中,我们通过分析 5 个公共数据集(GSE18842、GSE19804、GSE27262、GSE30219 和 GSE19188)比较了肺癌和正常肺样本之间的 PTTG3P 表达水平。接下来,构建磷酸戊糖通路和共表达网络以识别lncRNA PTTG3P的关键靶点。此外,还进行了基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 通路分析,以探索 lncRNA PTTG3P 的潜在作用。而且,我们在肺腺癌 (LUAD) 和肺鳞状细胞癌 (LUSC) 中构建了 PTTG3P 介导的 ceRNA 网络。结果在本研究中,我们的分析表明,PTTG3P 在高 T 期 LUAD 和 LUSC 样本以及高 N 期 NSCLC 组织中的表达较高。值得注意的是,我们通过分析 Kaplan-Meier 绘图仪数据集发现,较高的 PTTG3P 表达与 NSCLC 患者的较短生存时间相关。我们发现PTTG3P通过影响一系列细胞周期相关生物学过程与NSCLC细胞增殖调控显着相关。结论 生物信息学分析显示PTTG3P与NSCLC细胞增殖有关。这些结果表明 PTTG3P 可以作为 NSCLC 的新治疗和预后靶点。
更新日期:2020-03-09
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