INTRODUCTION Melatonin is a hormone used in the treatment of diverse pathologies due to its ability to regulate numerous physiological processes related to biological rhythms and neuroendocrine function. MATERIAL AND METHODS This study examines whether or not the antioxidant capacities of melatonin are modified during the creation of fast disintegrating oral tablets (FDDTs) through direct compression in which different concentrations of the active substance (3, 5, 10 and 60 mg) and excipients are made. In addition, the antioxidant capacity of melatonin is compared with that of reference antioxidants such as vitamin C, Trolox, resveratrol, glutathione and nicotinamide adenine dinucleotide phosphate (NADPH). RESULTS Melatonin has a lower antioxidant capacity only 5% of the capacity of resveratrol. Resveratrol is the compound having the greatest antioxidant capacity. As for the influence of the tablets components, it was found that only at higher concentrations of melatonin (60 mg/tablet), with the excipients mannitol, polyvinylpyrrolidone (crospovidone), magnesium stearate and anhydrous colloidal silica, did a decrease occur in the antioxidant capacity value, possibly due to the lower percentage of these excipients in the formulation.

中文翻译：

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有助于确定口腔分散片中褪黑激素的抗氧化能力 - 与参考抗氧化剂的比较。

引言褪黑激素是一种用于治疗多种疾病的激素，因为它能够调节与生物节律和神经内分泌功能相关的许多生理过程。材料和方法 本研究通过直接压制不同浓度的活性物质（3、5、10 和 60 毫克）和赋形剂，检查褪黑激素的抗氧化能力是否在快速崩解口服片剂 (FDDT) 的生产过程中得到改变被制作。此外，褪黑激素的抗氧化能力与维生素 C、Trolox、白藜芦醇、谷胱甘肽和烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 等参考抗氧化剂的抗氧化能力进行了比较。结果褪黑激素的抗氧化能力较低，仅为白藜芦醇能力的 5%。白藜芦醇是具有最大抗氧化能力的化合物。至于片剂成分的影响，发现只有在较高浓度的褪黑激素（60 mg/片）下，辅料为甘露醇、聚乙烯吡咯烷酮（交聚维酮）、硬脂酸镁和无水胶体二氧化硅，抗氧化剂的含量才会降低。容量值，可能是由于配方中这些辅料的百分比较低。