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Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis.
Archives of Medical Science ( IF 3.8 ) Pub Date : 2020-04-15 , DOI: 10.5114/aoms.2020.94433
Lanling Wang 1 , Chunlei Zhang 2 , Yuhuan Song 3 , Zhennan Zhang 4
Affiliation  

INTRODUCTION This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D. MATERIAL AND METHODS PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed. RESULTS The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = -0.71, 95% CI: -0.91, -0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07-1.23). Vitamin D was negatively correlated with HOMA-IR (r = -0.62, 95% CI: -0.85, -0.39). The analysis showed no publication bias (Egger's: p = 0.197; Begg's: p = 0.786). CONCLUSIONS Vitamin D is closely associated with the onset of GDM.

中文翻译:

血清维生素 D 缺乏和妊娠期糖尿病的风险:一项荟萃分析。

引言 这项荟萃分析旨在确认妊娠期糖尿病 (GDM) 和维生素 D 的关系。材料与方法 PubMed 和 CNKI 数据库搜索了相关文章。标准均数差 (SMD) 和 95% CI 用于比较 GDM 女性和健康受试者之间的维生素 D 水平。分析了维生素D与稳态模型评估-胰岛素抵抗指数(HOMA-IR)之间的相关系数。结果GDM受试者的维生素D水平远低于健康受试者(SMD = -0.71, 95% CI: -0.91, -0.50)。维生素 D 缺乏与 GDM 的高风险相关(OR = 1.15,95% CI:1.07-1.23)。维生素 D 与 HOMA-IR 呈负相关(r = -0.62, 95% CI: -0.85, -0.39)。分析显示没有发表偏倚(Egger's:p = 0.197;Begg's:p = 0.786)。
更新日期:2020-04-15
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