Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then a set of iodinated poly(p-dioxanone) (PPDO) fibers was fabricated via melt-spinning hybrid blends of PPDO with TIBA (PPDO/TIBA). The impact of TIBA content on the rheological behavior of blends was evaluated firstly. The physical, chemical, and thermal properties of PPDO/TIBA fibers were investigated accordingly by SEM, FTIR, DSC, and TGA. Moreover, the radiopaque property of PPDO/TIBA hybrid fibers as a potential radio-opacifying platform for medical devices was verified in vitro and in vivo. Finally, the accumulated release results of the hybrid fibers during in vitro degradation indicate the continual X-ray visibility of the hybrid fibers maintains for 22 days. This intriguing iodinated platform may pave the way for constructing fibrous materials with in-situ X-ray tracking property.

中文翻译：

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碘化聚（对二恶烷酮）作为可吸收植入式医疗器械 X 射线成像的简便平台。

目前，在目前的临床成像技术下，植入式纤维医疗器械仍然存在隐形的问题。为了解决这个问题，招募了 2, 3, 5-三碘苯甲酸 (TIBA) 作为造影剂，然后通过 PPDO 与TIBA (PPDO/TIBA)。首先评估了 TIBA 含量对共混物流变行为的影响。通过SEM、FTIR、DSC和TGA相应地研究了PPDO/TIBA纤维的物理、化学和热性能。此外，PPDO/TIBA 混合纤维作为医疗器械潜在的不透射线平台的不透射线特性在体外和体内得到了验证。最后，混合纤维在体外降解过程中的累积释放结果表明，混合纤维的连续 X 射线可见度保持了 22 天。这种有趣的碘化平台可能为构建具有原位 X 射线跟踪特性的纤维材料铺平道路。