Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contributes to zinc accumulation in Escherichia coli‐containing phagosomes, resulting in increased bacterial clearance.

中文翻译：

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Mϕs中的抗菌锌毒性：ZnT1付出了代价

包括锌在内的过渡金属对所有生物都是必不可少的。它们还具有很高的毒性，必须严格调节其细胞内浓度。在JLB的这一版中，Stocks等人。报告指出锌转运蛋白ZnT1（SLC30A1）是由Mϕs中的TLR4激活诱导的，其中它有助于锌在含大肠杆菌的吞噬体中的积累，从而增加细菌清除率。