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The Prospective Sense of Agency is Rooted in Local and Global Properties of Intrinsic Functional Brain Networks.
Journal of Cognitive Neuroscience ( IF 3.2 ) Pub Date : 2020-07-31 , DOI: 10.1162/jocn_a_01590
Simone Di Plinio 1 , Mauro Gianni Perrucci 1 , Sjoerd J H Ebisch 1
Affiliation  

The sense of agency (SoA) refers to a constitutional aspect of the self describing the extent to which individuals feel in control over their actions and consequences thereof. Although the SoA has been associated with mental health and well-being, it is still unknown how interindividual variability in the SoA is embedded in the intrinsic brain organization. We hypothesized that the prospective component of an implicit SoA is associated with brain networks related to SoA and sensorimotor predictions on multiple spatial scales. We replicated previous findings by showing a significant prospective SoA as indicated by intentional binding effects. Then, using task-free fMRI and graph analysis, we analyzed associations between intentional binding effects and the intrinsic brain organization at regional, modular, and whole-brain scales. The results showed that intermodular connections of a frontoparietal module including the premotor cortex, supramarginal gyrus, and dorsal precuneus are associated with individual differences in prospective intentional binding. Notably, prospective intentional binding effects were also related to global brain modularity within a specific structural resolution range. These findings suggest that an implicit SoA generated through sensorimotor predictions relies on the intrinsic organization of the brain connectome on both local and global scales.



中文翻译:

代理的前瞻性意识植根于内在功能性脑网络的局部和全局特性。

代理感 (SoA) 是指自我的构成方面,描述个人对自己的行为及其后果的控制程度。尽管 SoA 与心理健康和福祉有关,但 SoA 的个体间差异如何嵌入内在大脑组织中仍然未知。我们假设隐式 SoA 的预期成分与与 SoA 和多个空间尺度上的感觉运动预测相关的大脑网络相关。我们通过显示显着的前瞻性 SoA 来复制先前的发现,如有意结合效应所示。然后,使用无任务 fMRI 和图形分析,我们在区域、模块化和全脑尺度上分析了有意结合效应与内在大脑组织之间的关联。结果表明,包括运动前皮层、缘上回和楔前叶背在内的额顶模块的模块间连接与预期有意结合的个体差异有关。值得注意的是,预期的有意结合效应也与特定结构分辨率范围内的全局大脑模块化有关。这些发现表明,通过感觉运动预测产生的内隐 SoA 依赖于大脑连接组在局部和全局尺度上的内在组织。预期的有意结合效应也与特定结构分辨率范围内的全局大脑模块化有关。这些发现表明,通过感觉运动预测产生的内隐 SoA 依赖于大脑连接组在局部和全局尺度上的内在组织。预期的有意结合效应也与特定结构分辨率范围内的全局大脑模块化有关。这些发现表明,通过感觉运动预测产生的内隐 SoA 依赖于大脑连接组在局部和全局尺度上的内在组织。

更新日期:2020-08-20
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