BACKGROUND The possible gender impact on asthma arouses current and outstanding interest, but few studies addressed this issue in the real-world setting. OBJECTIVE This cross-sectional study tested the hypothesis of a potential difference between asthmatic males and females in a real-life setting, such as a third-level asthma clinic. METHODS A total of 499 asthmatic outpatients (301 females and 198 males, mean age 58.25 years) were consecutively visited. The visit included history, asthma control, and severity grade, physical examination, lung function, fractional exhaled nitric oxide assessment, and blood sample for biomarkers. RESULTS There were more females than males (about 3 of 5). Asthmatic females smoked less (p < 0.0001) than males and had higher FEV1 (p = 0.0022) and FVC (p = 0.0004) values than asthmatic males. CONCLUSIONS Gender difference was associated with smoking and lung function impairment; thus, this issue should be carefully considered in asthmatic patients in daily clinical practice.

中文翻译：

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现实世界中的哮喘：性别的相关性。

背景技术可能的性别影响对哮喘的影响引起了当前的兴趣，但很少有研究在现实世界中解决这个问题。目的这项横断面研究检验了在真实环境中（例如三级哮喘诊所）哮喘男性和女性之间潜在差异的假设。方法连续访问了499名哮喘门诊患者（女性301名，男性198名，平均年龄58.25岁）。该访视包括病史，哮喘控制和严重程度分级，体格检查，肺功能，呼出一氧化氮评估分数以及用于生物标志物的血液样本。结果女性多于男性（约占5分之3）。与哮喘男性相比，哮喘女性的吸烟量较少（p <0.0001），男性的FEV1（p = 0.0022）和FVC（p = 0.0004）较高。结论性别差异与吸烟和肺功能损害有关。因此，哮喘患者应在日常临床实践中认真考虑这个问题。