Models of mice carrying a human immune system, so‐called humanized mice, are used increasingly as preclinical models to bridge the gap between model organisms and human beings. Challenges of the humanized mouse model include finding suitable sources for human hematopoietic stem cells (HSC) and reaching sufficient engraftment of these cells in immunocompromised mice.

中文翻译：

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人源化小鼠模型：使用短串联重复技术的造血干细胞移植和追踪。

携带人类免疫系统的小鼠模型，即所谓的人源化小鼠，越来越多地被用作临床前模型，以弥合模型生物与人类之间的差距。人源化小鼠模型的挑战包括为人类造血干细胞 (HSC) 寻找合适的来源，以及在免疫功能低下的小鼠中充分植入这些细胞。