Introduction: 

Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects of exercise on longitudinal changes.

Methods: 

Clinically normal individuals completed a questionnaire on physical exercise over the prior 10-year period at baseline. Ninety-five individuals had serial cerebrospinal fluid samples collected to examine Aβ₄₂, ptau₁₈₁ and total tau; 181 individuals underwent multiple assessments of amyloid positron emission tomography imaging with Pittsburgh Compound-B; 327 individuals underwent multiple cognitive assessments, including measures of episodic memory, executive functions, verbal fluency, and processing speed.

Results: 

Greater exercise was associated with less steep decline in processing speed. Baseline exercise did not robustly impact longitudinal change for any other outcomes. Neither APOE nor BDNF genotype robustly moderated the effect of exercise on trajectories of AD biomarkers or cognitive decline.

Interpretation: 

Results suggest that self-reported physical exercise may be limited as a moderator of changes in AD biomarkers.

中文翻译：

---

阿尔茨海默病生物标志物和认知功能中的体育锻炼和纵向轨迹。

介绍： 

横断面观察到体育锻炼与阿尔茨海默病 (AD) 生物标志物和认知功能的关联。然而，运动对 AD 生物标志物纵向变化的影响尚未得到彻底研究。目前的研究检查了具有较高基线运动的个体是否在 AD 生物标志物和认知功能方面表现出较少的纵向变化，以及APOE和/或脑源性神经营养因子 ( BDNF ) 基因型是否调节了运动对纵向变化的影响。

方法： 

临床正常个体在基线时完成了过去 10 年期间的体育锻炼问卷。95 人采集了一系列脑脊液样本以检测 Aβ ₄₂、ptau ₁₈₁和总 tau；181 人使用匹兹堡化合物-B对淀粉样蛋白正电子发射断层扫描成像进行了多次评估；327 人接受了多项认知评估，包括情景记忆、执行功能、语言流利度和处理速度的测量。

结果： 

更多的运动与处理速度的急剧下降有关。基线练习并未对任何其他结果的纵向变化产生强烈影响。APOE和BDNF基因型都不能有力地调节运动对 AD 生物标志物轨迹或认知能力下降的影响。

解释： 

结果表明，作为 AD 生物标志物变化的调节剂，自我报告的体育锻炼可能受到限制。