Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular, cellular, anatomical, and functional insights. Development of advanced fluorescent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus imperative. To move forward in this direction, we developed an easy self-assembly method for fabricating aptamer-anchored rubrene-loaded organic fluorescent nanoprobes. The aptamer-modified organic nanoprobes integrated the best features of the organic light-emitting materials and the aptamers, thus endowing them with excellent cell-targeting capability, high stability, and good biocompatibility. By using this general method, a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

中文翻译：

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适体锚定的负载钌的有机纳米探针用于癌细胞靶向和成像

荧光成像已成为癌症研究中必不可少的技术，因为它可以揭示信息丰富的分子，细胞，解剖学和功能方面的见解。因此，必须开发出具有出色灵敏度和生物学选择性的先进荧光探针，以进行荧光成像。为了朝这个方向前进，我们开发了一种简单的自组装方法，用于制备适体锚定的负载红荧烯的有机荧光纳米探针。适体修饰的有机纳米探针结合了有机发光材料和适体的最佳功能，因此赋予它们优异的细胞靶向能力，高稳定性和良好的生物相容性。通过使用这种通用方法，