Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with rational monomer composition can direct architecture, self-assembly and chemical behavior, ultimately guiding the choice of appropriate application within the biomedical field. This review focuses on the applications of polypeptides alongside the synthetic advances in the ring opening polymerization of α-amino acid N-carboxyanhydrides achieved in the past five years. Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied.

中文翻译：

---

α-氨基酸的开环聚合：多肽及其杂化物的合成，结构和应用方面的进展。

多肽由于其固有的生物降解性和可调节的细胞相容性，在最近几十年中引起了相当大的关注。结合合理的单体组成的大分子设计可以指导结构，自组装和化学行为，最终指导生物医学领域内适当应用的选择。该综述着重于多肽的应用以及在过去五年中在α-氨基酸N-羧基酐的开环聚合中的合成进展。回顾了通过NCA ROP或与其他聚合方法结合获得的关键体系结构，因为它们在多肽应用的广泛应用中起着重要作用。