Automated peptide and oligonucleotide synthesizers enabled a revolution in molecular biology and helped pave the way to modern synthetic biology. Similarly, fully automated synthetic chemistry could herald a new wave of innovation in biology and materials sciences by greatly facilitating access to known and novel molecules. Here, we report on an automated multistep chemical synthesizer, AutoSyn, that makes milligram-to-gram-scale amounts of virtually any drug-like small molecule in a matter of hours and demonstrate its versatility with the synthesis of ten known drugs. Of the FDA-approved small-molecule drugs for which we were able to compute a synthetic route, 87% are predicted to be synthesizable on AutoSyn. Moreover, AutoSyn enables digital synthesis protocols that ensure the reproducibility and transferability of synthesis protocols from one lab to another.

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全自动化学合成：面向通用合成仪

自动化的肽和寡核苷酸合成仪引发了分子生物学的一场革命，并为现代合成生物学铺平了道路。同样，全自动合成化学可以极大地促进人们对已知和新颖分子的获取，从而预示着生物学和材料科学领域的新一波创新。在这里，我们报告了一种自动化的多步化学合成仪AutoSyn，该合成器可在几小时内使毫克级到克级的几乎任何药物样小分子生成，并证明了其在十种已知药物的合成中的多功能性。在我们能够计算出合成路线的FDA批准的小分子药物中，预计有87％可以在AutoSyn上合成。此外，