While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.

中文翻译：

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母体核苷 GS-441524 相对于瑞德西韦治疗 Covid-19 的优势。

尽管瑞德西韦因其温和的抗 Covid-19 功效而被寄予厚望，但其母体核苷 GS-441524 却被忽视了。瑞德西韦的药代动力学分析证明 GS-441524 的血清过早水解；GS-441524 是到达肺部的主要代谢物。凭借其合成简单性和在兽医环境中的体内功效，我们认为 GS-441524 在治疗 Covid-19 方面优于瑞德西韦。