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The Functional Convergence and Heterogeneity of Social, Episodic, and Self-Referential Thought in the Default Mode Network.
Cerebral Cortex ( IF 3.7 ) Pub Date : 2020-06-23 , DOI: 10.1093/cercor/bhaa166
Tanya Wen 1 , Daniel J Mitchell 1 , John Duncan 1, 2
Affiliation  

The default mode network (DMN) is engaged in a variety of cognitive settings, including social, semantic, temporal, spatial, and self-related tasks. Andrews-Hanna et al. (2010; Andrews-Hanna 2012) proposed that the DMN consists of three distinct functional–anatomical subsystems—a dorsal medial prefrontal cortex (dMPFC) subsystem that supports social cognition; a medial temporal lobe (MTL) subsystem that contributes to memory-based scene construction; and a set of midline core hubs that are especially involved in processing self-referential information. We examined activity in the DMN subsystems during six different tasks: 1) theory of mind, 2) moral dilemmas, 3) autobiographical memory, 4) spatial navigation, 5) self/other adjective judgment, and 6) a rest condition. At a broad level, we observed similar whole-brain activity maps for the six contrasts, and some response to every contrast in each of the three subsystems. In more detail, both univariate analysis and multivariate activity patterns showed partial functional separation, especially between dMPFC and MTL subsystems, though with less support for common activity across the midline core. Integrating social, spatial, self-related, and other aspects of a cognitive situation or episode, multiple components of the DMN may work closely together to provide the broad context for current mental activity.

中文翻译:

默认模式网络中社会、情景和自我指涉思想的功能收敛和异质性。

默认模式网络 (DMN) 从事各种认知设置,包括社交、语义、时间、空间和自我相关的任务。 安德鲁斯-汉娜等人。(2010;Andrews-Hanna 2012) 提出 DMN 由三个不同的功能解剖子系统组成——一个支持社会认知的背内侧前额叶皮层 (dMPFC) 子系统;内侧颞叶 (MTL) 子系统,有助于基于记忆的场景构建;和一组中线核心中枢,特别涉及处理自我参考信息。我们在六个不同的任务中检查了 DMN 子系统中的活动:1) 心理理论,2) 道德困境,3) 自传体记忆,4) 空间导航,5) 自我/其他形容词判断,以及 6) 休息条件。在广泛的层面上,我们观察到六个对比的相似全脑活动图,以及对三个子系统中每个对比的一些反应。更详细地说,单变量分析和多变量活动模式均显示部分功能分离,尤其是在 dMPFC 和 MTL 子系统之间,尽管对中线核心的常见活动支持较少。整合社会、空间、自我相关和认知情况或事件的其他方面,DMN 的多个组成部分可以紧密合作,为当前的心理活动提供广泛的背景。
更新日期:2020-06-23
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