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COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
Cerebral Cortex ( IF 3.7 ) Pub Date : 2020-06-23 , DOI: 10.1093/cercor/bhaa137
Isabel Del Pino 1, 2 , Chiara Tocco 3 , Elia Magrinelli 3, 4 , Andrea Marcantoni 5 , Celeste Ferraguto 3 , Giulia Tomagra 5 , Michele Bertacchi 3 , Christian Alfano 3 , Xavier Leinekugel 1 , Andreas Frick 1 , Michèle Studer 3
Affiliation  

The formation of functional cortical maps in the cerebral cortex results from a timely regulated interaction between intrinsic genetic mechanisms and electrical activity. To understand how transcriptional regulation influences network activity and neuronal excitability within the neocortex, we used mice deficient for Nr2f1 (also known as COUP-TFI), a key determinant of primary somatosensory (S1) area specification during development. We found that the cortical loss of Nr2f1 impacts on spontaneous network activity and synchronization of S1 cortex at perinatal stages. In addition, we observed alterations in the intrinsic excitability and morphological features of layer V pyramidal neurons. Accordingly, we identified distinct voltage-gated ion channels regulated by Nr2f1 that might directly influence intrinsic bioelectrical properties during critical time windows of S1 cortex specification. Altogether, our data suggest a tight link between Nr2f1 and neuronal excitability in the developmental sequence that ultimately sculpts the emergence of cortical network activity within the immature neocortex.

中文翻译:

COUP-TFI/Nr2f1 在体感皮层发育过程中协调内在神经元活动。

大脑皮层功能皮层图的形成是内在遗传机制和电活动之间及时调节的相互作用的结果。为了了解转录调控如何影响新皮质内的网络活动和神经元兴奋性,我们使用了Nr2f1(也称为COUP-TFI)缺陷的小鼠,Nr2f1是发育过程中初级体感 (S1) 区域规范的关键决定因素。我们发现Nr2f1的皮质丢失围产期对自发网络活动和 S1 皮层同步的影响。此外,我们观察到 V 层锥体神经元的内在兴奋性和形态特征的改变。因此,我们确定了由Nr2f1调节的不同电压门控离子通道,它们可能在 S1 皮层规范的关键时间窗口内直接影响内在生物电特性。总而言之,我们的数据表明Nr2f1与发育序列中的神经元兴奋性之间存在紧密联系,最终塑造了未成熟新皮层内皮层网络活动的出现。
更新日期:2020-06-23
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