The present review provides a comprehensive outlook toward the possibilities of developing a functional in vitro liver tissue model on a paper platform. To this end, we first addressed the suitability of using a cellulose-based paper matrix as a substrate for cell culture applications. Then, we highlighted various patterning and substrate modification strategies that have been exploited to make the paper matrix cell-friendly. Finally, we provide an overview of the current advancements made toward developing paper-based liver tissue models and the challenges and opportunities the field has encountered.

中文翻译：

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纸基细胞培养：为在纤维素纸芯片上开发肝组织模型铺平道路

本综述全面展望了在纸质平台上开发功能性体外肝组织模型的可能性。为此，我们首先解决了使用基于纤维素的纸基质作为细胞培养应用基质的适用性。然后，我们重点介绍了各种图案化和基板修饰策略，这些策略已被用来使纸基质细胞友好。最后，我们概述了目前在开发纸质肝组织模型方面取得的进展以及该领域遇到的挑战和机遇。