Endothelial lipase (LIPG/EL) performs fundamental and vital roles in the human body, including cell composition, cytokine expression, and energy provision. Since LIPG predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves in the metabolic syndromes such as inflammatory response and atherosclerosis. Cytokines significantly affect LIPG expression in endothelial cells in many diseases. Recently, it is suggested that LIPG contributes to cancer initiation and progression, and LIPG attached increasing importance to its potential for future targeted therapy.

内皮脂肪酶 (LIPG/EL) 在人体中发挥着基本和重要的作用，包括细胞组成、细胞因子表达和能量供应。由于 LIPG 主要作为磷脂酶起作用，并且甘油三酯脂肪酶活性水平较低，因此它在脂蛋白代谢中起重要作用，并参与炎症反应和动脉粥样硬化等代谢综合征。在许多疾病中，细胞因子显着影响内皮细胞中 LIPG 的表达。最近，有人提出 LIPG 有助于癌症的发生和发展，并且 LIPG 越来越重视其未来靶向治疗的潜力。