The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone/quinol‐binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc1, and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.

中文翻译：

---

细胞色素 bc 1 复合物作为抗病原体靶标

细胞色素 bc1 复合物是许多真核微生物线粒体呼吸链的关键组成部分，这些微生物对植物或人类具有致病性，例如导致作物病害的真菌和导致人类疟疾的恶性疟原虫。细胞色素 bc1 是一种含有两个 (泛) 醌/喹啉结合位点的酶，可用于开发杀真菌剂和化疗剂。在这里，我们回顾了最近在确定细胞色素 bc1 的结构和作用机制方面取得的进展，以及针对其活性的抗菌剂（和相关耐药机制）的相关开发。