当前位置: X-MOL 学术Stem Cells Transl. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mesenchymal stem cells as a multimodal treatment for nervous system diseases.
STEM CELLS Translational Medicine ( IF 6 ) Pub Date : 2020-06-23 , DOI: 10.1002/sctm.19-0430
Bogna Badyra 1 , Maciej Sułkowski 1 , Olga Milczarek 2 , Marcin Majka 1
Affiliation  

Neurological disorders are a massive challenge for modern medicine. Apart from the fact that this group of diseases is the second leading cause of death worldwide, the majority of patients have no access to any possible effective and standardized treatment after being diagnosed, leaving them and their families helpless. This is the reason why such great emphasis is being placed on the development of new, more effective methods to treat neurological patients. Regenerative medicine opens new therapeutic approaches in neurology, including the use of cell‐based therapies. In this review, we focus on summarizing one of the cell sources that can be applied as a multimodal treatment tool to overcome the complex issue of neurodegeneration—mesenchymal stem cells (MSCs). Apart from the highly proven safety of this approach, beneficial effects connected to this type of treatment have been observed. This review presents modes of action of MSCs, explained on the basis of data from vast in vitro and preclinical studies, and we summarize the effects of using these cells in clinical trial settings. Finally, we stress what improvements have already been made to clarify the exact mechanism of MSCs action, and we discuss potential ways to improve the introduction of MSC‐based therapies in clinics. In summary, we propose that more insightful and methodical optimization, by combining careful preparation and administration, can enable use of multimodal MSCs as an effective, tailored cell therapy suited to specific neurological disorders.

中文翻译:

间充质干细胞作为神经系统疾病的多模式治疗。

神经系统疾病是现代医学面临的巨大挑战。除了该类疾病是全球第二大死亡原因之外,大多数患者在确诊后无法获得任何可能的有效、规范的治疗,让他们及其家人束手无策。这就是为什么如此重视开发新的、更有效的方法来治疗神经系统患者的原因。再生医学开辟了神经病学的新治疗方法,包括使用基于细胞的疗法。在这篇综述中,我们重点总结了一种可以作为多模式治疗工具来克服神经退行性疾病复杂问题的细胞来源——间充质干细胞(MSC)。除了这种方法的安全性得到充分证明外,还观察到与这种治疗相关的有益效果。这篇综述介绍了 MSC 的作用模式,并根据大量体外和临床前研究的数据进行了解释,并总结了在临床试验环境中使用这些细胞的效果。最后,我们强调已经做出了哪些改进来阐明 MSC 作用的确切机制,并讨论了改进基于 MSC 的疗法在临床中的引入的潜在方法。总之,我们建议,通过结合仔细的制备和管理,进行更有洞察力和更有条理的优化,可以使多模式间充质干细胞成为一种有效的、适合特定神经系统疾病的定制细胞疗法。
更新日期:2020-06-23
down
wechat
bug