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HPLC-SPE-NMR analysis of furanosesquiterpenoids from bark exudates of Commiphora swynnertonii Burrt
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2020-06-23 , DOI: 10.1016/j.phytol.2020.06.006
Willbrord M. Kalala , Kenn Foubert , Luc Pieters , Sheila Maregesi

Bark exudate of the tree Commiphora swynnertonii Burtt. (Burseraceae) is used by ethnic groups in Northern Tanzania and Southern Kenya, to treat various diseases in humans and to kill ectoparasites infesting livestock. The acaricidal activity has been demonstrated in vitro and in vivo. The aim of this study was to isolate the main constituents of the exudate. The exudate was fractionated by Flash Chromatography, purified by HPLC-SPE and subjected to NMR analysis for structural elucidation. Five furanosesquiterpenoids were isolated and identified as 6-oxodendrolasin, (E)-6-oxoisodendrolasin, (Z)-6-oxoisodendrolasin, crassifolone and 7,8-dihydroisodendrolasin, the latter one being reported here for the first time.



中文翻译:

Swynnertonii Burrt树皮分泌液中呋喃呋喃萜的HPLC-SPE-NMR分析

Commiphora swynnertonii Burtt的树皮分泌物。(蒲桃科)被坦桑尼亚北部和肯尼亚南部的族裔用来治疗人类的各种疾病并杀死家畜中的外寄生虫。杀螨活性已在体外体内得到证实。这项研究的目的是分离渗出液的主要成分。通过快速色谱分离渗出液,通过HPLC-SPE纯化,并进行NMR分析以阐明结构。分离出5种呋喃半萜类化合物,鉴定为6-氧杂松氨酸,(E) -6-氧杂异松散蛋白,(Z)-6-氧代异松果糖苷,克拉索酮和7,8-二氢异树突康蛋白,后者是首次在此报道。

更新日期:2020-06-23
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