Classical neural circuitry models of posttraumatic stress disorder (PTSD) are largely derived from univariate activation studies and implicate the fronto-limbic circuit as a main neural correlate of PTSD symptoms. Though well-supported by human neuroimaging literature, these models are limited in their ability to explain the widely distributed neural and behavioral deficits in PTSD. Emerging interest in the application of large-scale network methods to functional neuroimaging provides a new opportunity to overcome such limitations and conceptualize the neural circuitry of PTSD in the context of network patterns. This review aims to evaluate both the classical neural circuitry model and a new, network-based model of PTSD neural circuitry using a breadth of functional brain organization research in subjects with PTSD. Taken together, this literature suggests global patterns of reduced functional connectivity (FC) in PTSD groups as well as altered FC targets that reside disproportionately in canonical functional networks, especially the default mode network. This provides evidence for an integrative model that includes elements of both the classical models and network-based models to characterize the neural circuitry of PTSD.

创伤后应激障碍 (PTSD) 的经典神经回路模型主要源自单变量激活研究，并暗示额叶边缘回路是 PTSD 症状的主要神经相关因素。尽管得到人类神经影像学文献的充分支持，但这些模型解释 PTSD 中广泛分布的神经和行为缺陷的能力有限。人们对将大规模网络方法应用于功能性神经影像的兴趣日益浓厚，这为克服这些限制并在网络模式的背景下概念化 PTSD 的神经回路提供了新的机会。本综述旨在利用对 PTSD 受试者进行广泛的功能性大脑组织研究来评估经典神经回路模型和基于网络的新型 PTSD 神经回路模型。总而言之，该文献提出了 PTSD 群体中功能​​连接（FC）减少的全局模式，以及不成比例地存在于规范功能网络（尤其是默认模式网络）中的改变的 FC 目标。这为综合模型提供了证据，该模型包括经典模型和基于网络的模型的元素来表征 PTSD 的神经回路。