A realistic/comprehensive biomechanical model of right/left coronary arteries is developed using the in vivo geometric and haemodynamic properties obtained from optical coherence tomography (OCT), angiography, and electrocardiography (ECG). The developed biomechanical model is constructed with the help of an image processing technique and simulated via the finite element method (FEM) for determination of regions with highest shear/von Mises stresses (which determine the potential areas for plaque rupture and initiation of myocardial infarction). A set of simulation results is compared to clinically obtained data to assess the validity of modelling/simulations. The model comprehensively incorporates information relating to three dimensionality, realistic geometry, hyper/viscoelasticity, blood viscosity, heart motion, blood pulsation, and artery bed (i.e. surrounding heart tissue). In vivo clinical data from two patients who underwent coronary angiography for clinical indications is used for modelling/simulations, one of whom had a mild (20%) stenosis in the left circumflex artery and the other had a right coronary artery (RCA) which was initially 100% occluded in its mid segment (following aspiration thrombectomy to remove clot, the RCA was left with diffuse mild (30–40%) narrowing) and then OCT was used to examine this further and showed proximal thin-capped lipid-rich plaque.

使用从光学相干断层扫描（OCT），血管造影和心电图（ECG）获得的体内几何和血液动力学特性，开发了右/左冠状动脉的现实/综合生物力学模型。借助图像处理技术构建开发的生物力学模型，并通过有限元方法（FEM）进行模拟，以确定剪切/冯·米塞斯应力最高的区域（确定斑块破裂和心肌梗死的潜在区域） 。将一组模拟结果与临床获得的数据进行比较，以评估建模/模拟的有效性。该模型全面整合了与三维，现实几何，超/粘弹性，血液粘度，心脏运动，血液搏动，和动脉床（即周围的心脏组织）。来自两名接受冠状动脉造影以作为临床指征的患者的体内临床数据用于建模/模拟，其中一名左旋支轻度狭窄（20％），另一名右冠状动脉（RCA）狭窄。最初在其中段被100％阻塞（在进行了抽吸血栓切除术以去除血凝块之后，RCA的弥漫性轻度狭窄（30–40％）变窄），然后使用OCT对其进行了进一步检查，并显示了近端稀疏的脂质丰富的斑块。