Abstract The hydrazone ligand (HL) was synthesized from furan-2-carbohydrazide and indole-3-carboxaldehyde. The reaction of [RuCl2(p-cymene)]2 with HL in the presence of sodium methoxide yielded organometallic Ru(II)-p-cymene compound of the type [RuCl(η6-p-cymene)(η2-N,O-indole hydrazone)] (1). The ligand and complex were characterized by CHN analysis and various spectroscopic tools. The piano stool (pseudo-octahedral) geometry of the complex was confirmed by single crystal X-ray diffraction. The anticancer property of the ligand and complex was investigated against A549, HeLa and MCF7 cancer cell lines. The complex exhibited superior activity against A549 and HeLa cancer cells with the IC50 values of 23.4 and 12.9 µM, respectively.

中文翻译：

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含杂环腙配体的半夹心 Ru(II)-对伞花烃复合物的抗癌活性增强

摘要 以呋喃-2-碳酰肼和吲哚-3-甲醛为原料合成了腙配体(HL)。[RuCl2(p-cymene)]2 与 HL 在甲醇钠存在下反应生成 [RuCl(η6-p-cymene)(η2-N,O-吲哚腙)] (1). 配体和复合物通过 CHN 分析和各种光谱工具进行表征。通过单晶 X 射线衍射证实了复合物的钢琴凳（伪八面体）几何形状。针对 A549、HeLa 和 MCF7 癌细胞系研究了配体和复合物的抗癌特性。该复合物对 A549 和 HeLa 癌细胞表现出优异的活性，IC50 值分别为 23.4 和 12.9 µM。