Objective

To ascertain the prevalence of Müllerian anomalies within an obstetrical population in relation to official hazardous waste sites designated by the Environmental Protection Agency (EPA) in West Virginia.

Methods

Observational study of obstetric patients in a tertiary care center with uterine ultrasounds from January 2006 to June 2017. An Optimized Hot Spot analysis and Ripley's K- Function was constructed to ascertain if there is an association with environmental exposures.

Results

The prevalence of Müllerian anomalies in our obstetric study sample was 0.9% (118/13,040). The most common were septate (47; 39.8%) and bicornuate (46; 39.0%). The distribution of Müllerian anomalies was non-random illustrated by Optimized Hot Spot Analysis locating several statistically significant zip codes of Müllerian anomalies in relation to zip codes that include EPA facilities.

Conclusion

The distribution of Müllerian anomalies was clustered in watershed areas along the Kanawha River in West Virginia that have been designated as EPA FRS Sites and Superfund Sites.

中文翻译：

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工业流域对产科人群缪勒氏异常影响的生态研究。

目的

为了确定相对于西弗吉尼亚州环境保护局（EPA）指定的官方危险废物场所，产科人群中缪勒氏异常的患病率。

方法

2006年1月至2017年6月在三级护理中心接受子宫超声检查的产科患者的观察性研究。构建了优化的热点分析和Ripley的K函数，以确定是否与环境暴露有关。

结果

在我们的产科研究样本中，苗勒氏异常的患病率为0.9％（118 / 13,040）。最常见的是分隔的（47； 39.8％）和双角蛋白（46； 39.0％）。优化热点分析以非随机的方式说明了米勒异常的分布，该数据针对包含EPA设施的米勒异常的几个统计上显着的邮政编码进行了定位。

结论

Müllerian异常的分布集中在西弗吉尼亚州卡纳瓦哈河沿岸的分水岭地区，这些地区被指定为EPA FRS站点和Superfund站点。