Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71.4%). Median age at diagnosis was 47 years, and median follow-up duration was 60 months (IQR 29–75). Mean calcium level at diagnosis was 12.7 mg/dL (range, 11.3–13.9), and mean parathormone level was 1115 ng/L (IQR 287–1470). Two patients (28.5%) had a palpable neck mass. Coexisting brown tumor was present in three patients (42.8%), and nephrolithiasis was found in one patient (14.2). Average tumor size was 29 mm (IQR 28–40). Capsular and vascular invasion were detected in six patients (85.7%), intrathyroidal spread was observed in two patients (28.5%), and soft tissue invasion was seen in three patients (42.8%). Parathyroid adenoma was present in one patient and parathyroid gland hyperplasia in another patient. Adjuvant radiotherapy was given to four patients (57.1%). There was no metastatic disease or death. At the last visit, two patients had increased parathormone levels and no additional focus could be detected in either. Patients with markedly elevated parathormone and calcium levels and a palpable larger mass on the neck should be evaluated for parathyroid cancer. En bloc resection is the mainstay treatment. Despite contradictory results, adjuvant radiotherapy to the neck may help to reduce the risk of local recurrence in patients with microscopic residual parathyroid carcinoma.

甲状旁腺癌是一种罕见的恶性肿瘤，也是甲状旁腺功能亢进的罕见原因。在本研究中，我们介绍了 7 例甲状旁腺癌病例。女性比例为 5/7 (71.4%)。诊断时的中位年龄为 47 岁，中位随访时间为 60 个月（IQR 29-75）。诊断时的平均钙水平为 12.7 mg/dL（范围，11.3-13.9），平均甲状旁腺激素水平为 1115 ng/L（IQR 287-1470）。两名患者 (28.5%) 有可触及的颈部肿块。3 名患者（42.8%）共存棕色肿瘤，1 名患者（14.2%）发现肾结石。平均肿瘤大小为 29 毫米（IQR 28-40）。6 名患者（85.7%）检测到包膜和血管侵犯，2 名患者（28.5%）观察到甲状腺内扩散，3 名患者（42.8%）观察到软组织侵犯。一名患者出现甲状旁腺腺瘤，另一名患者出现甲状旁腺增生。4 名患者（57.1%）接受了辅助放疗。没有转移性疾病或死亡。在最后一次就诊时，两名患者的甲状旁腺激素水平升高，并且两人均未检测到额外的病灶。甲状旁腺癌的甲状旁腺癌应评估甲状旁腺癌。整块切除术是主要治疗方法。尽管结果相互矛盾，但颈部辅助放疗可能有助于降低微小残留甲状旁腺癌患者局部复发的风险。两名患者的甲状旁腺激素水平升高，并且两人均未检测到额外的病灶。甲状旁腺癌的甲状旁腺癌患者应评估甲状旁腺癌的甲状旁腺癌。整块切除术是主要治疗方法。尽管结果相互矛盾，但颈部辅助放疗可能有助于降低微小残留甲状旁腺癌患者局部复发的风险。两名患者的甲状旁腺激素水平升高，并且两人均未检测到额外的病灶。甲状旁腺癌的甲状旁腺癌应评估甲状旁腺癌。整块切除术是主要治疗方法。尽管结果相互矛盾，但颈部辅助放疗可能有助于降低微小残留甲状旁腺癌患者局部复发的风险。