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Copper-catalyzed regioselective sulfonylcyanations of vinylarenes
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2020-06-22 , DOI: 10.1039/d0qo00415d
Lei Liu 1, 2, 3, 4 , Mingran Si 1, 2, 3, 4 , Shengnan Han 1, 2, 3, 4 , Yan Zhang 1, 2, 3, 4 , Jie Li 1, 2, 3, 4, 5
Affiliation  

A set of copper-catalyzed sulfonylcyanations of vinylarenes with readily accessible arylsulfonyl chlorides and trimethyl cyanide was accomplished under mild conditions, thus providing a step-economic streamlined route to various decorated β-sulfonyl nitriles with good regioselectivity and functional group tolerance. Preliminary mechanistic studies suggested that this type of reaction undergoes a classic radical chain process.

中文翻译:

铜催化乙烯基芳烃的区域选择性磺酰基氰化

在温和的条件下完成了一组铜催化的乙烯基芳烃的磺酰基氰基与易得的芳基磺酰氯和三甲基氰化物的反应,从而为具有良好的区域选择性和官能团耐受性的各种修饰的β-磺酰基腈提供了经济高效的步骤。初步的机理研究表明,这种类型的反应经历了经典的自由基链过程。
更新日期:2020-07-28
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