Isoxazoles and their derivatives represent privileged heteroaromatic motifs, which exhibit remarkable biological and pharmaceutical activities. Notably, metal catalyzed or mediated cyclization/functionalization of alkynes such as alkynone oxime ethers, acetylinic oximes, propargylic amino ethers, alkynyl nitrile oxides, and propargylic alcohols has recently attracted much attention from synthetic organic chemists because of their high efficiency in the assembly of structurally diverse isoxazole architectures under mild conditions with exceptional chemo-, stereo- and regioselectivities. In this review, a wide array of metal catalysts, such as palladium, copper, iron, gold, silver, and other metals, have been summarized and discussed in detail. Moreover, we also highlight some representative synthetic strategies along with reaction mechanisms involved during the reaction. And, the literature has been surveyed from 2010 until the beginning of 2020.

中文翻译：

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金属催化或介导炔烃环化/官能化以构建异恶唑的最新进展

异恶唑及其衍生物代表特权的杂芳族基序，表现出显着的生物学和药学活性。值得注意的是，由于炔烃在组装结构上的高效率，金属的催化或介导的炔烃如炔炔肟醚，炔属肟，炔丙基氨基醚，炔基腈氧化物和炔丙醇的环化/官能化最近引起了合成有机化学家的广泛关注。温和条件下具有多种异恶唑结构，具有出色的化学，立体和区域选择性。在这篇综述中，已经对各种金属催化剂，例如钯，铜，铁，金，银和其他金属进行了总结和详细讨论。此外，我们还将重点介绍一些代表性的合成策略以及反应过程中涉及的反应机理。并且，从2010年到2020年初对文献进行了调查。