Polydentate chelators are an important part of an imaging probe, which consists of an agent that usually produces signals for imaging purposes connected to a targeting moiety. The goal of this study was to set up a generic protocol to prepare a library of polydentate ligands having a 6-amino-6-methyl-1,4-perhydrodiazepine (AMPED) core and able to chelate metal ions of interest for various diagnostic imaging techniques, including Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT). These ions, among which we can include Mn(II), Cu(II), Al(III) or Ga(III), require penta- or hexa-dentate chelators for this purpose, and the AMPED scaffold has considerable potential to support various pendant arms for coordination of such ions. AMPED already has three amino nitrogen donors; thus, only two or three additional arms should be introduced to obtain penta- or hexa-dentate systems. This condition implies that symmetrical or asymmetrical structures have to be developed, depending on the functionalization of cyclic and exocyclic amines. Starting from easily available materials, we have designed a convenient protocol for the preparation of multiple AMPED-based ligands endowed with different characteristics, several of which were synthesized as examples.

中文翻译：

---

用于合成多齿螯合剂文库的6-氨基-6-甲基-1,4-全氢二氮杂pine的选择性官能化。

多齿螯合剂是成像探针的重要部分，该探针由通常会产生用于成像目的的信号的试剂连接到靶向部分上。这项研究的目的是建立一个通用协议，以制备具有6-氨基-6-甲基-1,4-过氢二氮杂（AMPED）核并能够螯合感兴趣的金属离子以进行各种诊断成像的多齿配体库技术，包括磁共振成像（MRI），正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）。这些离子包括Mn（II），Cu（II），Al（III）或Ga（III）），为此目的需要五齿或六齿螯合剂，而AMPED支架具有相当大的潜力来支持各种悬垂臂来协调这些离子。AMPED已经有三个氨基氮供体；因此，仅应引入两个或三个附加臂来获得五齿或六齿系统。该条件暗示取决于环状和环外胺的官能化，必须开发对称或不对称结构。从容易获得的材料开始，我们设计了一种方便的方案，用于制备具有不同特性的多种基于AMPED的配体，其中一些是作为示例合成的。