The aim of this study was to investigate the application of optical coefficients obtained from cross-polarization optical coherence tomography (CP OCT) data to differentiate breast cancer tissues from normal breast tissues. For this, surgically obtained breast specimens from 35 patients were investigated using CP OCT in order to construct pseudocolor en face OCT maps based on a calculation of three optical coefficients: the commonly used, rate of attenuation in the co-channel (Att co- ) and, additionally, the attenuation in the cross-channel (Att cross- ); and the interchannel attenuation difference (uD). It was shown that the use of these optical coefficients significantly increased the information available from the OCT data in comparison with unprocessed images, and that this enabled objective quantification for differentiating non-tumorous and tumorous tissue (adipose tissue, normal stroma, tumor stroma and agglomerates of tumor cells). The Att c...

中文翻译：

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从交叉极化OCT数据估算组织光学特性，以评估乳腺癌的边缘

这项研究的目的是研究从交叉偏振光学相干断层扫描（CP OCT）数据获得的光学系数在区分乳腺癌组织和正常乳腺组织中的应用。为此，使用CP OCT对35例患者的外科手术乳房标本进行了研究，以便基于以下三个光学系数的计算来构建伪彩色的OCT贴图：常用的同频衰减率（Att co-）另外，交叉通道中的衰减（Att cross-）；以及通道间衰减差（uD）。结果表明，与未处理的图像相比，这些光学系数的使用大大增加了OCT数据的可用信息，从而可以客观定量区分非肿瘤组织和肿瘤组织（脂肪组织，正常基质，肿瘤基质和肿瘤细胞的聚集体）。Att c ...