LIN28B is involved in multiple cellular developmental processes, tissue inflammatory response and tumourigenesis. The association of LIN28B polymorphisms with hepatitis B virus (HBV) infection remains unknown. This study investigated the association of LIN28B rs314277, rs314280, rs369065 and rs7759938 polymorphisms in patients with chronic HBV infection, a major cause of liver disease including hepatocellular carcinoma (HCC). A total of 781 individuals including 515 cases of chronic HBV infection (91 asymptomatic carrier status, 128 chronic hepatitis, 127 cirrhosis and 169 HCC), 97 HBV infection resolvers and 169 healthy controls were investigated. LIN28 rs314280 genotypes GA + AA were higher in resolver and controls than patients (P = 0.011). Patients had significantly lower rs314280 allele A than resolvers (P = 0.031, OR 0.689, 95%CI 0.491–0.969) or controls (P = 0.034, OR 0.741, 95%CI 0.561–0.978). In dominant model, patients had significantly lower rs314280 genotypes AA+GA than controls (P = 0.008, OR 0.623, 95%CI 0.439–0.884). LIN28 rs7759938 genotypes TC + CC were higher in resolvers and controls than patients (P = 0.015). Patients had significantly lower rs7759938 allele C than resolvers (P = 0.048, OR 0.708, 95%CI 0.503–0.999). In dominant model, patients had significantly lower rs7759938 genotypes TC + CC than controls (P = 0.010, OR 0.632, 95%CI 0.445–0.897). Chronic hepatitis patients had lower frequency of rs369065 genotype TC than asymptomatic carriers, cirrhosis and HCC (P = 0.019). These results suggest that LIN28 rs314280 and rs7759938 may be related to the susceptibility of chronic HBV infection. Further studies are warranted to examine the association of LIN28B polymorphisms with HBV-related diseases, especially HCC.

中文翻译：

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LIN28B多态性与慢性乙型肝炎病毒感染的关联。

LIN28B参与多个细胞发育过程，组织炎症反应和肿瘤发生。LIN28B基因多态性与乙型肝炎病毒（HBV）感染的关联仍然未知。这项研究调查了LIN28B rs314277，rs314280，rs369065和rs7759938多态性与慢性HBV感染患者的关系，慢性HBV感染是包括肝细胞癌（HCC）在内的肝脏疾病的主要原因。共调查了781人，包括515例慢性HBV感染（91例无症状携带者，128例慢性肝炎，127例肝硬化和169例HCC），97例HBV感染缓解者和169例健康对照者。解析器和对照中LIN28 rs314280基因型GA + AA高于患者（P = 0.011）。患者的rs314280等位基因A显着低于解析者（P = 0.031，OR 0.689，95％CI 0.491-0。969）或对照（P = 0.034，或0.741，95％CI 0.561–0.978）。在优势模型中，患者的rs314280基因型AA + GA显着低于对照组（P = 0.008，或0.623，95％CI 0.439-0.884）。解析器和对照中LIN28 rs7759938基因型TC + CC高于患者（P = 0.015）。患者的rs7759938等位基因C显着低于解析者（P = 0.048，或0.708，95％CI 0.503-0.999）。在显性模型中，患者的rs7759938基因型TC + CC显着低于对照组（P = 0.010，或0.632，95％CI 0.445–0.897）。慢性肝炎患者的rs369065基因型TC发生率低于无症状携带者，肝硬化和肝癌（P = 0.019）。这些结果表明，LIN28 rs314280和rs7759938可能与慢性HBV感染的易感性有关。