Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to assess these aspects. Our retrospective cohort study enrolled and analyzed 353 follow-up cases that underwent first AVF creation. The artery and vein sizes were measured by ultrasound. We performed follow-up, a minimum of 3 months after surgery. Multivariable logistic regression analysis was used to identify independent risk factors inmaturation. Participant age was categorized into four groups (age ≤ 29, 30–49, 50–69, and 70–90 years). Radial artery diameter was categorized into four groups (≤ 1.9, >1.9 and ≤ 2.1, >2.1 and ≤ 2.4, >2.4 mm) according to median and interquartile ranges. We adjusted for confounders in four logistic models, and primary analyses were based on building ordered category models and tested P values for trends to estimate the relationship of radial artery diameter and each 20-year increase in age with risk of maturation. The mature RCAVF group included 301 cases, and the immature group included 52 cases. Radial artery diameter, age, and diabetes were independent risk factors of maturation. Odds ratios (ORs) associated with maturation reduced with increasing age, while ORs increased with increasing radial artery diameter. P values for trends(<0.05) were observed in all four models. A reduction in radial artery diameter and higher age were significantly associated with a higher incidence of immaturity after adjusting the multivariate models. The risks of immaturation were increased by more than 1.54 fold for each 20-year increase and increased by more than 1.34 fold for the smaller radial artery diameter group. Our findings suggest that a significantly higher immaturity risk of RCAVF was associated with increasing age and a reduction in radial artery diameter. Our study identified a linear exposure-response relationship of age and radial artery diameter with immaturity incident. A careful selection of patients will be helpful in improving AVF functional maturation.

中文翻译：

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桡骨-头动静脉瘘的桡动脉直径和与年龄相关的功能成熟。

以前的研究没有描述桡动脉直径减小与放射-头动静脉瘘 (RCAVF) 年龄增加和功能成熟之间的关系，也没有数据将这些确定为线性关系。本研究的目的是进行趋势分析以评估这些方面。我们的回顾性队列研究招募并分析了 353 例首次创建 AVF 的随访病例。通过超声测量动脉和静脉的大小。我们进行了随访，至少在手术后 3 个月。多变量逻辑回归分析用于识别独立危险因素成熟。参与者年龄分为四组（年龄≤ 29、30-49、50-69 和 70-90 岁）。桡动脉直径分为四组（≤ 1.9、> 1.9 和 ≤ 2.1、> 2.1 和 ≤ 2.4、> 2。4 毫米）根据中位数和四分位距。我们调整了四个逻辑模型中的混杂因素，主要分析基于构建有序类别模型并测试趋势的 P 值，以估计桡动脉直径和年龄每增加 20 年与成熟风险之间的关系。成熟RCAVF组301例，未成熟组52例。桡动脉直径、年龄和糖尿病是成熟的独立危险因素。与成熟相关的优势比（ORs）随着年龄的增加而降低，而ORs随着桡动脉直径的增加而增加。在所有四个模型中都观察到趋势的 P 值（<0.05）。在调整多变量模型后，桡动脉直径的减小和年龄的增加与不成熟的较高发生率显着相关。每增加 20 年，未成熟风险增加 1.54 倍以上，桡动脉直径较小组增加 1.34 倍以上。我们的研究结果表明，显着较高的 RCAVF 未成熟风险与年龄增加和桡动脉直径减小有关。我们的研究确定了年龄和桡动脉直径与不成熟事件的线性暴露-反应关系。仔细选择患者将有助于改善 AVF 功能的成熟。我们的研究确定了年龄和桡动脉直径与不成熟事件的线性暴露-反应关系。仔细选择患者将有助于改善 AVF 功能的成熟。我们的研究确定了年龄和桡动脉直径与不成熟事件的线性暴露-反应关系。仔细选择患者将有助于改善 AVF 功能的成熟。