Arteriosclerosis is prevalent in patients with chronic kidney disease (CKD). Our aims were to investigate (1) the effects of 12 months of either balance- or strength- both in combination with endurance training on abdominal aortic calcification (AAC); on some lipids and calcific- and inflammatory markers; and (2) the relationships between the change in AAC score and these markers in non-dialysis dependent patients with CKD stages 3 to 5. One hundred twelve patients (mean age 67 ± 13 years), who completed 12 months of exercise training; comprising either balance- or strength training, both in combination with endurance training; with a measured glomerular filtration rate (mGFR) 22.6 ± 8 mL/min/1.73m2, were included in this study. AAC was evaluated with lateral lumbar X-ray using the scoring system described by Kauppila. Plasma fetuin-A, fibroblast growth factor 23 (FGF23) and interleukin 6 (IL6) were measured with Enzyme-linked immunosorbent assay (ELISA) kits. After 12 months of exercise training, the AAC score increased significantly in both groups; mGFR and lipoprotein (a) decreased significantly in both groups; parathyroid hormone (PTH) and 1,25(OH)2D3 increased significantly only in the strength group; fetuin-A increased significantly only in the balance group. Plasma triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, FGF23, phosphate, calcium, IL6, C-reactive protein (CRP), albumin were unchanged. The increase in AAC score was positively related to ageing and the levels of baseline triglycerides and lipoprotein (a). Exercise training did not prevent the progression of AAC; it might have contributed to the reduced levels of lipoprotein (a) and unchanged levels of calcific- and inflammatory markers in these patients with non-dialysis dependent CKD. Hypertriglyceridemia, high levels of lipoprotein (a) and ageing emerged as longitudinal predictors of vascular calcification in these patients. NCT02041156 at www.ClinicalTrials.gov. Date of registration: January 20, 2014. Retrospectively registered.

中文翻译：

---

12 个月的运动训练并没有阻止 CKD 患者的腹主动脉钙化 - RENEXC 的一项子研究 - 一项随机对照试验。

动脉硬化在慢性肾脏病 (CKD) 患者中很普遍。我们的目的是调查 (1) 12 个月的平衡或力量训练结合耐力训练对腹主动脉钙化 (AAC) 的影响；在一些脂质和钙化和炎症标志物上；(2) CKD 3~5期非透析依赖患者AAC评分变化与这些标志物的关系。112名患者（平均年龄67±13岁）完成12个月的运动训练；包括平衡训练或力量训练，两者都与耐力训练相结合；本研究包括测量的肾小球滤过率 (mGFR) 22.6 ± 8 mL/min/1.73m2。AAC 使用 Kauppila 描述的评分系统通过侧位腰椎 X 射线进行评估。血浆胎球蛋白-A，成纤维细胞生长因子 23 (FGF23) 和白细胞介素 6 (IL6) 用酶联免疫吸附测定 (ELISA) 试剂盒测量。运动训练12个月后，两组AAC评分均显着升高；两组的 mGFR 和脂蛋白 (a) 均显着降低；甲状旁腺激素 (PTH) 和 1,25(OH)2D3 仅在力量组中显着增加；胎球蛋白-A 仅在平衡组中显着增加。血浆甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、FGF23、磷酸盐、钙、IL6、C反应蛋白（CRP）、白蛋白没有变化。AAC 评分的增加与衰老以及基线甘油三酯和脂蛋白 (a) 的水平呈正相关。运动训练并没有阻止 AAC 的进展；它可能导致这些非透析依赖性 CKD 患者的脂蛋白 (a) 水平降低和钙化和炎症标志物水平不变。高甘油三酯血症、高水平的脂蛋白 (a) 和衰老成为这些患者血管钙化的纵向预测因素。www.ClinicalTrials.gov 上的 NCT02041156。注册日期：2014年1月20日，追溯注册。