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Standing on the Shoulders of Viruses.
Annual Review of Biochemistry ( IF 16.6 ) Pub Date : 2020-06-22 , DOI: 10.1146/annurev-biochem-011320-103928
Ari Helenius 1
Affiliation  

My coworkers and I have used animal viruses and their interaction with host cells to investigate cellular processes difficult to study by other means. This approach has allowed us to branch out in many directions, including membrane protein characterization, endocytosis, secretion, protein folding, quality control, and glycobiology. At the same time, our aim has been to employ cell biological approaches to expand the fundamental understanding of animal viruses and their pathogenic lifestyles. We have studied mechanisms of host cell entry and the uncoating of incoming viruses as well as the synthesis, folding, maturation, and intracellular movement of viral proteins and molecular assemblies. I have had the privilege to work in institutions in four different countries. The early years in Finland (the University of Helsinki) were followed by 6 years in Germany (European Molecular Biology Laboratory), 16 years in the United States (Yale School of Medicine), and 16 years in Switzerland (ETH Zurich).

中文翻译:


站在病毒的肩膀上。

我和我的同事们已经使用动物病毒及其与宿主细胞的相互作用来研究难以通过其他方式研究的细胞过程。这种方法使我们可以在许多方向上分支,包括膜蛋白表征,内吞作用,分泌,蛋白折叠,质量控制和糖生物学。同时,我们的目标是采用细胞生物学方法来扩展对动物病毒及其病原性生活方式的基本了解。我们研究了宿主细胞进入机制和传入病毒的脱壳机制,以及病毒蛋白和分子装配体的合成,折叠,成熟和细胞内运动。我有幸在四个不同国家的机构工作。

更新日期:2020-06-23
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