The approval of anti-TNF therapy for colitis over 20 years ago represented a paradigm shift for the treatment of this disease. Anti-TNF therapy is now shown to prevent colitis-associated colon cancer in mice by modifying the gut microbiota composition and transcriptional activity, including genes in Escherichia coli that control colibactin synthesis.

中文翻译：

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TNF形状的微生物群促进癌症

20 多年前批准抗 TNF 治疗结肠炎代表了治疗这种疾病的范式转变。抗 TNF 疗法现在被证明可以通过改变肠道微生物群组成和转录活性来预防小鼠结肠炎相关的结肠癌，包括控制大肠杆菌素合成的大肠杆菌中的基因。