Abstract In this study we report on the preparation and characterization of biocomposites based on a sodium montmorillonite-ibuprofen (MtIb) hybrid and neat poly(ethylene glycol), neat sodium carboxymethylcellulose or poly(ethylene glycol)-carboxymethylcellulose blend 50/50 biocomposites as drug carriers. Ib, a poorly soluble drug, was first intercalated into sodium Mt and then the resulting hybrid was compounded with the different polymeric matrices. Ib incorporation efficiency in Mt was determined by UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and thermal analysis. Both X-ray diffraction and differential scanning calorimetric studies revealed that the intercalation of Ib between the clay layers induced amorphization of the drug. Differential scanning calorimetry and Fourier transform infrared spectroscopy revealed the development of strong interactions between Ib and the polymer matrix. A study of the release of Ib from the synthesized biocomposites in simulated intestinal fluid (pH 7.4) was investigated. To better understand the release mechanism of drug molecules from the different carriers, several kinetic models have been applied.

中文翻译：

---

粘土/（PEG-CMC）生物复合材料作为布洛芬的新型递送系统

摘要 在本研究中，我们报告了基于蒙脱石钠-布洛芬 (MtIb) 杂化和纯聚（乙二醇）、纯羧甲基纤维素钠或聚（乙二醇）-羧甲基纤维素共混物 50/50 生物复合材料作为药物的生物复合材料的制备和表征。载体。Ib 是一种难溶性药物，首先插入 Mt 钠中，然后将所得杂化物与不同的聚合物基质混合。通过紫外-可见光谱、傅里叶变换红外光谱、X 射线衍射和热分析测定 Ib 在 Mt 中的结合效率。X 射线衍射和差示扫描量热研究均表明粘土层之间的 Ib 嵌入诱导了药物的非晶化。差示扫描量热法和傅里叶变换红外光谱揭示了 Ib 和聚合物基质之间强相互作用的发展。研究了 Ib 从模拟肠液 (pH 7.4) 中合成的生物复合材料中的释放。为了更好地了解药物分子从不同载体中的释放机制，已经应用了几种动力学模型。