Several Na⁺‐dependent phosphate cotransporters, namely NaPi‐IIb/SLC34A2, Pit‐1/SLC20A1 and Pit‐2/SLC20A2, are expressed at the apical membrane of enterocytes but their contribution to active absorption of phosphate is unclear. The aim of this study was to compare their pattern of mRNA expression along the small and large intestine and to analyse the effect of intestinal depletion of Pit‐2 on phosphate homeostasis.

中文翻译：

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小鼠中 Pit-2/Slc20a2 的肠上皮消融导致维生素 D3 在饮食限制磷酸盐后持续升高。

几种 Na ⁺依赖性磷酸盐协同转运蛋白，即 NaPi-IIb/SLC34A2、Pit-1/SLC20A1 和 Pit-2/SLC20A2，在肠细胞的顶膜上表达，但它们对磷酸盐主动吸收的贡献尚不清楚。本研究的目的是比较它们沿小肠和大肠的 mRNA 表达模式，并分析肠道中 Pit-2 耗竭对磷酸盐稳态的影响。