Toxoplasma gondii and Cryptosporidium spp. can cause devastating pathological effects in humans and livestock, and in particular to young or immunocompromised individuals. The current treatment plans for these enteric parasites are limited due to long drug courses, severe side effects or simply a lack of efficacy. The study of the early interactions between the parasites and the site of infection in the small intestinal epithelium has been thwarted by the lack of accessible, physiologically relevant and species‐specific models. Increasingly, 3D stem cell‐derived enteroid models are being refined and developed into sophisticated models of infectious disease. In this review, we shall illustrate the use of enteroids to spearhead research into enteric parasitic infections, bridging the gap between cell line cultures and in vivo experiments.

中文翻译：

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干细胞源性肠样培养物作为解剖小肠上皮细胞宿主-寄生虫相互作用的工具

弓形虫和隐孢子虫spp。可能对人类和家畜，尤其是年轻或免疫功能低下的人造成破坏性的病理影响。由于长期的药物疗程，严重的副作用或仅缺乏疗效，目前针对这些肠寄生虫的治疗计划有限。由于缺乏可及的，生理相关的和物种特异性的模型，对小肠上皮中的寄生虫和感染部位之间的早期相互作用的研究受到了阻碍。越来越多的3D干细胞源肠样模型被完善并发展成为复杂的传染病模型。在这篇综述中，我们将举例说明使用类肠素来带头研究肠道寄生虫感染，弥合细胞系培养与体内实验之间的差距。